NaltrexLow™ is our exclusive brand of LDN - Low-Dose Naltrexone. ‘LDN’ refers to the use of naltrexone at low doses; typically less than 5 mg per day. LDN was discovered at Penn State University in 1980 and was first shown to slow down the growth of cancer. Twenty years later, researchers discovered that LDN also helps treat autoimmune and inflammatory diseases and chronic pain conditions. LDN is now used by >500,000 people worldwide, and over 100 studies have been published in the medical literature covering its use for more than 60 medical conditions.

LDN is unmatched by any other drug. Through LDN’s effects on normalizing immune system function and cell division rates, LDN is gaining recognition by researchers worldwide as the safest drug with the broadest range of applications in medicine.

What’s the Difference Between LDN and regular Naltrexone?

Naltrexone (high dose, 50 - 100 mg daily) is FDA approved for reducing opiate and alcohol addictions. However, as in many cases - less is often more. High dose naltrexone is not effective for treating the wide range of conditions which are helped specifically by Low Dose Naltrexone. Only the low dose of naltrexone, by staying in the body for a very short time, allows the normalization of endorphin production and immune function. These benefits however are neutralized by high dose naltrexone.

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NaltrexLow™ comes in various doses, to suit everyone’s individual needs.
The optimal dose for NaltrexLow™ varies between users, and we offer different dosage forms to accommodate as many users as possible.

Which dose is right for you?
The standard dose used in clinical trials for adults has been 4.5 mg. The most optimal individualized dose depends on bodyweight and individual metabolic function. The optimal dose can be found through starting low and building up in 0.5 mg increments until the most effective dose is achieved.

People with thyroid disorders who are taking thyroid medication are strongly advised to begin with lower doses first. This is due to LDN’s improvement of thyroid function and the need to reduce thyroid medication slowly.

What is NaltrexLow™ (LDN) Used For?

LDN is being used as an immune system modifier, providing relief to patients with autoimmune and inflammatory diseases, viral diseases and central nervous system disorders.

It is also being used to treat pain disorders. Since 2002, over 80 leading universities have performed studies or published their experiences with using LDN for over 50 medical conditions that are caused by a dysregulated immune system; from multiple sclerosis, Crohn’s, rheumatoid arthritis, lupus, thyroid disorders, fibromyalgia, psoriasis, to cancer and HIV - NaltrexLow™ offers hope for a brighter future.

To see the most up to date list of diseases and disorders for which LDN works or is being studied, visit the constantly-updates list at LDNscience

NaltrexLow™ Questions & Answers

  1. How does NaltrexLow™ - LDN work?

    Endorphins (feel-good molecules) are produced in most cells in the body and are important regulators of cell growth and the immune system. Disorders of the immune system can occur when endorphins are at unusually low levels.

    Low dose naltrexone is a drug that binds to the body’s natural opiate ( endorphin) receptors for a short time. The body, feeling starved of natural endorphins (opiates), is now tricked to significantly increase its production of endorphins. Once the low-dose naltrexone stops blocking the opiate receptors (usually in 2- 3 hours), the body is then able to benefit from the hugely increased levels of endorphins circulating in the bloodstream. This is known as “the rebound effect”.

    The benefits of the rebound effect can only be utilized by taking a low dose of regular naltrexone. Taking a high dose of naltrexone or using a slow-release formulation will continue to block the opioid receptors and no benefit can be achieved from the elevated endorphin levels.

    Individuals vary in their metabolic speed and this will result in variations of the speed at which LDN is eliminated from the body, as well as the length of the rebound effect. A single daily dose of between 3 mg and 4.5 mg works well for most people, however some people benefit from building up their dose slowly or taking even two doses daily.

    To watch a short video explaining how LDN works, click here.

  2. How quickly does NaltrexLow™ - LDN work?

    Some patients experience a very fast response to LDN; immediately or within days of taking it. In many cases, the response becomes evident after about two weeks of use. In some cases, especially those of long standing chronic conditions, it has taken up to two months for benefit to accrue. LDN doesn’t work for everyone, however it is a very safe drug - so it is reasonable to wait up to 2 - 3 months to assess the intensity of its effect.

  3. When should I take NaltrexLow™ - LDN?

    Although many people take LDN in the evening or before sleep, scientific studies have shown that it is equally effective if taken during the day. This is important for those people who sometimes experience sleep disturbances as result of LDN.

  4. Which medications must be avoided when using NaltrexLow™ (LDN)?

    LDN should not be combined with any opiate-based drugs, as LDN can cancel their effects. Many painkillers are opiate-based. Drugs such as Imodium® are also opiate-based and LDN may neutralize its effect.

  5. What are the side effects of NaltrexLow™ (LDN)?

    Side effects from LDN are unusual. Sleep disturbances sometimes happen during the first few days of use, if taken at night. This can be avoided by taking it earlier in the day. Vivid dreams are reported more frequently. Low dose naltrexone is considered safe and non-toxic.

  6. Can I use NaltrexLow™ (LDN) while pregnant or breastfeeding?

    The use of any medicinal product during pregnancy or breastfeeding should be discussed with your physician.

Low Dose Naltrexone (LDN) Resources

For further information about LDN, please visit the non-profit LDN educational site,