WHAT IS LDD?
LDD is short for Low Dose Dipyridamole.
Dipyridamole is a drug that was approved by the US FDA in 1961 to prevent blood clots. More recently, it was also approved for preventing strokes. The typical daily dose is 200 - 400mg. LDD refers to using dipyridamole at very small doses, typically less than 10 mg daily. That is 1/20th to 1/40th of the regular dose. The effects of LDD were discovered at Ariel University Center for Drug Repurposing (CDR) in Israel. We are proud to collaborate with the scientists at CDR and provides the same dipyridamole used in their studies. The concept of LDD bears great resemblance to that of LDN (low dose naltrexone) in that low dose is essential for therapy success. LDD too provides effects at low dose that do not happen at high dose. ‘LDD’ is presently undergoing studies to uncover and clarify its unique mode of action across a number of disorders.
WHAT IS LDD GOOD FOR?
There is no published research yet about LDD. However, it is being researched for several disorders, and there has been positive feedback from patients for whom it has been prescribed. Since dipyridamole is an approved drug - physicians are able to prescribe at low dose, which is then prepared by a compounding pharmacy. LDD is being researched or prescribed for the following conditions:
- Dry eye (keratoconjunctivitis sicca)
- Dry mouth (xerostomia)
- Erectile dysfunction
- Viral disease (colds, flu) prevention and treatment
HOW DOES LDD WORK?
The answer is not yet known, and theoretical mechanisms are being explored.
HOW QUICKLY DOES LDD WORK?
Dry eye: symptomatic relief is typically felt within days with once-a-day dosing.
Dry mouth: reduction in severity is noticeable within a few days, and increased relief is achieved over time, with once-a-day dosing.
Insomnia: improved sleep is typically achieved within 1 - 2 days with once-a-day dosing.
Erectile dysfunction: restoration of penile tumescence (night-time erections) happens within days to a couple of weeks with once-a-day dosing.
Viral diseases: LDD has been used successfully to reduce the frequency of viral infections (colds and flu) with long-term once-a-day dosing. When a viral infection sets in, taking LDD reduces the duration of the illness as well as its severity (sore throat for example). For an active viral infection, dosing is increased to twice-daily. A higher dose (such as 5 mg may be used once or twice daily during the course of a viral infection).
WHICH DOSE DO I NEED?
The optimal dose for an adult seems to be 2 mg once-daily, and for a child it is 1mg daily. However, dipyridamole absorption is very dependent on stomach acid levels. With age or with antacid use, stomach acid levels decline and this impairs the absorption of LDD. Therefore some users may require 5mg pills to achieve the same effects that others would with 2 mg.
WHAT SIDE EFFECTS DOES LDD CAUSE?
So far the only side effects observed are excessive sleep (dose can be lowered) and increased dream intensity. The increase in dream intensity is described by some as improved dream recall. This effect is not observed by everyone. It should be noted that many users find the increased dream intensity very pleasurable, while for others it has taken some time to adjust to it. LDD is very safe. Dipyridamole is typically used at doses 100 to 200 times that of LDD, and is considered safe even at the very high doses. Even high dose dipyridamole is safely used during pregnancy.
WHEN SHOULD LDD BE TAKEN?
Many people take LDD in the evening hours, two to three hours after the evening meal. This is a good time especially if the intention is to improve sleep. However it can be taken in the morning or any time during the day. It should ideally be taken on an empty stomach to increase absorption.
WHICH MEDICATIONS MUST BE AVOIDED WHEN USING LDD?
There are no known issues in combining LDD with any other medications.