LDD™ is our exclusive brand of Low Dose Dipyridamole. LDD™ capsules contain 2 mg of dipyridamole per capsule. Dipyridamole was approved by the US FDA in 1961 to prevent blood clots, and more recently it was additionally approved for preventing strokes. The typical daily dose is 200 - 400 mg. LDD™ refers to using dipyridamole at very low doses, typically less than 10 mg daily.

Low dose dipyridamole is being studied for treating insomnia (sleep disorders), dry eye disease (DED), pain disorders including fibromyalgia, viral infections, and anxiety. LDD™ was discovered by researchers in Israel, is patented worldwide, and is sold under license from the patent holders. The concept of LDD™ bears great resemblance to that of LDN (low dose naltrexone) in that low dose is essential for therapy success. LDD™ too provides benefits only at low doses that do not occur at high doses. The exact novel mechanism of action of low dose dipyridamole is still being researched.

Did you know?

Dipyridamole comes in various forms. In high dose (25 mg - 200 mg pills) it is sold under the brand names Persantin®, Persantine®, Curantyl®, Cardoxin®, and Aggrenox®. It is also available in injectable form (10 mg injections). Dipyridamole is being developed in eye drop form for treating eye disorders. Low dose dipyridamole is available under license exclusively from us, under our trade name LDD™.

LDD™ (Low Dose Dipyridamole) Products

What is LDD™ (Low Dose Dipyridamole) Used For?

LDD™ is currently being used for treating insomnia (sleep disorders), dry eye (keratoconjunctivitis sicca), dry mouth (xerostomia), erectile dysfunction, pain disorders including fibromyalgia, and prevention and treatment of viral disease in adults and children.

NaltrexLow™ Questions & Answers

  1. What does LDD™ stand for?

    LDD is short for Low-Dose Dipyridamole. It is provided in capsules for oral use.

  2. What is Low-Dose Dipyridamole?

    Dipyridamole is a drug that was approved by the US FDA in 1961 to prevent blood clots. More recently, it was also approved for preventing strokes. The typical daily dose is 200 - 400 mg. ‘LDD’ refers to using dipyridamole at very small doses, typically less than 10 mg daily. That is 1/20th to 1/40th of the regular dose. Paradoxically, LDD™ provides effects at low dose that do not happen at high dose.

  3. Which medical conditions can benefit, or be treated with LDD™?

    There is no published research yet about LDD. However, it is being researched for several disorders, and there has been positive feedback from patients for whom it has been prescribed. Since dipyridamole is an approved drug - physicians are able to prescribe at low dose, which is then prepared by a compounding pharmacy. LDD™ is being researched or prescribed for the following conditions:
    ● Dry eye (keratoconjunctivitis sicca)
    ● Dry mouth (xerostomia)
    ● Insomnia
    ● Erectile dysfunction
    ● Relief of pain
    ● Viral disease (colds, flu) prevention and treatment

  4. How does LDD™ work?

    The answer is not yet known, and theoretical mechanisms are being explored.

  5. How quickly does LDD™ work?

    Dry eye: symptomatic relief is typically felt within days with once-a-day dosing.

    Dry mouth: reduction in severity is noticeable within a few days, and increased relief is achieved over time, with once-a-day dosing.

    Insomnia: improved sleep is typically achieved within 1 - 2 days with once-a-day dosing in the evening.

    Erectile dysfunction: restoration of penile tumescence (night-time erections) happens within days to a couple of weeks with once-a-day dosing.

    Viral diseases: LDD™ has been used successfully to reduce the frequency of viral infections (colds and flu) with long-term once-a-day dosing. When a viral infection sets in, taking LDD™ reduces the duration of the illness as well as its severity (sore throat, for example). For an active viral infection, dosing is increased to twice-daily. A higher dose (such as 5 mg may be used once or twice daily during the course of a viral infection).

  6. Which dose do I need?

    The optimal dose is 2 mg once-daily for an adult, and 1 mg daily for a child. However, dipyridamole absorption is very dependent on stomach acid levels. With age or with antacid use, stomach acid levels decline, impairing the absorption of LDD™. Therefore, some users may require 5 mg pills to achieve the same effects that others would experience with 2 mg.

  7. When should LDD™ be taken?

    Many people take LDD™ in the evening hours, two to three hours after the evening meal. This is a good time especially if the intention is to improve sleep. However, it can be taken in the morning or any time during the day. It should ideally be taken on an empty stomach to increase absorption, as stomach acid levels are highest when the stomach is empty.

  8. Which medications must be avoided when using LDD™?

    There are no known issues in combining LDD™ with any other medications.

  9. What are the side effects of LDD™?

    To date, the only side effects observed are excessive sleep (dose can be lowered) and increased dream intensity. The increase in dream intensity is described by some as improved dream recall. This effect is not observed by everyone. It should be noted that many users find the increased dream intensity very pleasurable, while for others it has taken some time to adjust to it. LDD™ is very safe. Dipyridamole is typically used at doses 100 to 200 times that of LDD™ and is considered safe even at the very high doses.

  10. Can I use LDD™ while pregnant?

    The use of any medicinal product during pregnancy should be discussed with your physician. Dipyridamole is typically used at doses 100 to 200 times that of LDD™ and is considered safe even at the very high doses. Even high-dose dipyridamole is safely used during pregnancy.